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Publications 2017

Intracerebroventricular Delivery in Mice for Motor Neuron Diseases.

Nizzardo M, Rizzuti M.

Methods Mol Biol 2017 - 01/07/2017

MicroRNA-Directed Neuronal Reprogramming as a Therapeutic Strategy for Neurological Diseases.

Faravelli I, Corti S.

Mol Neurobiol. 2017 - 29/06/2017

Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis.

Crisafulli SG, Brajkovic S, Cipolat Mis MS, Parente V, Corti S.

Mol Neurobiol. 2017 - 28/04/2017

MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis.

Rinchetti P, Rizzuti M, Faravelli I, Corti S.

Mol Neurobiol. 2017 - 18/04/2017

Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown-Vialetto disease that is partially rescued by riboflavin.

Rizzo F, Ramirez A, Compagnucci C, Salani S, Melzi V, Bordoni A, Fortunato F, Niceforo A, Bresolin N, Comi GP, Bertini E, Nizzardo M, Corti S.

Sci Rep. 2017 - 06/04/2017

Publications 2016

iPSC-derived LewisX+CXCR4+β1-integrin+ neural stem cells improve the amyotrophic lateral sclerosis phenotype by preserving motor neurons and muscle innervation in human and rodent models.

Nizzardo M, Bucchia M, Ramirez A, Trombetta E, Bresolin N, Comi GP, Corti S. Hum Mol Genet. 2016 Aug 1;25(15):3152-3163.

Hum Mol Genet 2016 - 01/08/2016

Development of Therapeutics for C9ORF72 ALS/FTD-Related Disorders.

Mis MS, Brajkovic S, Tafuri F, Bresolin N, Comi GP, Corti S.

Mol Neurobiol 2016 - 28/06/2016

Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS.

Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez JA, Cao M, Corti S, Hedlund E.

Sci Rep 2016 - 16/05/2016

Experimental Advances Towards Neural Regeneration from Induced Stem Cells to Direct In Vivo Reprogramming.

Dametti S, Faravelli I, Ruggieri M, Ramirez A, Nizzardo M, Corti S.

Mol Neurobiol 2016 - 01/05/2016

Autophagy in motor neuron disease: Key pathogenetic mechanisms and therapeutic targets.

Cipolat Mis MS, Brajkovic S, Frattini E, Di Fonzo A, Corti S.

Mol Cell Neurosci 2016 - 01/04/2016

Is spinal muscular atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?

Simone C, Ramirez A, Bucchia M, Rinchetti P, Rideout H, Papadimitriou D, Re DB, Corti S

Cell Mol Life Sci 2016 - 01/03/2016

Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype.

Nizzardo M, Simone C, Rizzo F, Ulzi G, Ramirez A, Rizzuti M, Bordoni A, Bucchia M, Gatti S, Bresolin N, Comi GP, Corti S.

Sci Rep 2016 - 16/02/2016

Publications 2015

Clinical and molecular features and therapeutic perspectives of spinal muscular atrophy with respiratory distress type 1.

Vanoli F, Rinchetti P, Porro F, Parente V, Corti S.

J Cell Mol Med 2015 - 19/09/2015

MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives.

Stuppia G, Rizzo F, Riboldi G, Del Bo R, Nizzardo M, Simone C, Comi GP, Bresolin N, Corti S.

J Neurol Sci 2015 - 15/09/2015

SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis.

Tafuri F, Ronchi D, Magri F, Comi GP, Corti S.

Front Cell Neurosci 2015 - 25/08/2015

Spinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches.

Nizzardo M, Simone C, Dametti S, Salani S, Ulzi G, Pagliarani S, Rizzo F, Frattini E, Pagani F, Bresolin N, Comi G, Corti S.

Sci Rep. 2015 - 30/06/2015

Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery.

Corti S, Faravelli I, Cardano M, Conti L.

Expert Opin Drug Discov 2015 - 15/06/2015

Spinal muscular atrophy–recent therapeutic advances for an old challenge.

Faravelli I, Nizzardo M, Comi GP, Corti S.

Nat Rev Neurol 2015 - 11/06/2015

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS.

Comley L, Allodi I, Nichterwitz S, Nizzardo M, Simone C, Corti S, Hedlund E.

Neuroscience 2015 - 16/04/2015

Gene therapy rescues disease phenotype in a spinal muscular atrophy with respiratory distress type 1 (SMARD1) mouse model.

Nizzardo M, Simone C, Rizzo F, Salani S, Dametti S, Rinchetti P, Del Bo R, Foust K, Kaspar BK, Bresolin N, Comi GP, Corti S.

Sci Adv 2015 - 13/03/2015

Therapeutic development in amyotrophic lateral sclerosis.

Bucchia M, Ramirez A, Parente V, Simone C, Nizzardo M, Magri F, Dametti S, Corti S.

Clin Ther 2015 - 01/03/2015

Pluripotent stem cell-based models of spinal muscular atrophy

Frattini E, Ruggieri M, Salani S, Faravelli I, Zanetta C, Nizzardo M, Simone C, Magri F, Corti S.

Mol Cell Neurosci 2015 - 10/01/2015

Therapeutic applications of the cell-penetrating HIV-1 Tat peptide

Rizzuti M, Nizzardo M, Zanetta C, Ramirez A, Corti S.

Drug Discov Today 2015 - 01/01/2015

Publications 2014

Antisense oligonucleotide therapy for the treatment of C9ORF72 ALS/FTD diseases

Riboldi G, Zanetta C, Ranieri M, Nizzardo M, Simone C, Magri F, Bresolin N, Comi GP, Corti S.

Parkinsonism Relat Disord. 2015 - 01/12/2014

The wide spectrum of clinical phenotypes of spinal muscular atrophy with respiratory distress type 1: a systematic review

Porro F, Rinchetti P, Magri F, Riboldi G, Nizzardo M, Simone C, Zanetta C, Faravelli I, Corti S.

J Neurol Sci 2014 - 15/11/2014

iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development

Faravelli I, Frattini E, Ramirez A, Stuppia G, Nizzardo M, Corti S.

J Clin Med 2014 - 17/10/2014

Stem cell transplantation for amyotrophic lateral sclerosis: therapeutic potential and perspectives on clinical translation.

Faravelli I, Riboldi G, Nizzardo M, Simone C, Zanetta C, Bresolin N, Comi GP, Corti S.

Cell Mol Life Sci 2014 - 01/09/2014

iPSC-Derived neural stem cells act via kinase inhibition to exert neuroprotective effects in spinal muscular atrophy with respiratory distress type 1.

Simone C, Nizzardo M, Rizzo F, Ruggieri M, Riboldi G, Salani S, Bucchia M, Bresolin N, Comi GP, Corti S.

Stem Cell Reports 2014 - 12/08/2014

Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives.

Faravelli I, Bucchia M, Rinchetti P, Nizzardo M, Simone C, Frattini E, Corti S

Stem Cell Res Ther 2014 - 14/07/2014

In vitro neurogenesis: development and functional implications of iPSC technology.

Compagnucci C, Nizzardo M, Corti S, Zanni G, Bertini E.

Cell Mol Life Sci 2014 - 01/05/2014

Induced neural stem cells: methods of reprogramming and potential therapeutic applications.

Ruggieri M, Riboldi G, Brajkovic S, Bucchia M, Bresolin N, Comi GP, Corti S.

Prog Neurobiol. 2014 - 15/03/2014

Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis.

Rizzo F, Riboldi G, Salani S, Nizzardo M, Simone C, Corti S, Hedlund E.

Cell Mol Life Sci 2014 - 07/03/2014

Effect of combined systemic and local morpholino treatment on the spinal muscular atrophy Δ7 mouse model phenotype.

Nizzardo M, Simone C, Salani S, Ruepp MD, Rizzo F, Ruggieri M, Zanetta C, Brajkovic S, Moulton HM, Müehlemann O, Bresolin N, Comi GP, Corti S.

Clin Ther 2014 - 01/03/2014

Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model.

Nizzardo M, Simone C, Rizzo F, Ruggieri M, Salani S, Riboldi G, Faravelli I, Zanetta C, Bresolin N, Comi GP, Corti S.

Hum Mol Genet. 2014 Jan - 15/01/2014

Molecular therapeutic strategies for spinal muscular atrophies: current and future clinical trials.

Zanetta C, Nizzardo M, Simone C, Monguzzi E, Bresolin N, Comi GP, Corti S.

Clin Ther. 2014 Jan - 01/01/2014

Publications 2013

Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model.

Nizzardo M, Simone C, Rizzo F, Ruggieri M, Salani S, Riboldi G, Faravelli I, Zanetta C, Bresolin N, Comi GP, Corti S.

Hum Mol Genet. 2013 - 04/09/2013

Cellular Therapy to Target Neuroinflammation in Amyotrophic Lateral Sclerosis.

Federica Rizzo, Giulietta Riboldi, Sabrina Salani, Monica Nizzardo, Chiara Simone, Stefania Corti1*, Eva Hedlund2*.

Cell Mol Life Sci. 2013 - 31/07/2013

Riboflavin transporter 3 involvement in infantile Brown-Vialetto-Van Laere disease: two novel mutations.

Ciccolella M, Corti S, Catteruccia M, Petrini S, Tozzi G, Rizza T, Carrozzo R, Nizzardo M, Bordoni A, Ronchi D, D'Amico A, Rizzo C, Comi GP, Bertini E.

J Med Genet. 2013 - 28/02/2013

Publications 2012

Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy.

Corti S, Nizzardo M, Simone C, Falcone M, Nardini M, Ronchi D, Donadoni C, Salani S, Riboldi G, Magri F, Menozzi G, Bonaglia C, Rizzo F, Bresolin N, Comi GP.

Sci Transl Med. 2012 - 19/12/2012

Direct reprogramming of human astrocytes into neural stem cells and neurons.

Corti S, Nizzardo M, Simone C, Falcone M, Donadoni C, Salani S, Rizzo F, Nardini M, Riboldi G, Magri F, Zanetta C, Faravelli I, Bresolin N, Comi GP.

Exp Cell Res. 2012 - 01/08/2012

Research advances in gene therapy approaches for the treatment of amyotrophic lateral sclerosis.

Nizzardo M, Simone C, Falcone M, Riboldi G, Rizzo F, Magri F, Bresolin N, Comi GP, Corti S.

Cell Mol Life Sci. 2012 - 31/05/2012

Publications 2011

ALS genetic modifiers that increase survival of SOD1 mice and are suitable for therapeutic development.

Riboldi G, Nizzardo M, Simone C, Falcone M, Bresolin N, Comi GP, Corti S.

Prog Neurobiol. 2011 - 31/10/2011

Beta-lactam antibiotic offers neuroprotection in a spinal muscular atrophy model by multiple mechanisms.

Nizzardo M, Nardini M, Ronchi D, Salani S, Donadoni C, Fortunato F, Colciago G, Falcone M, Simone C, Riboldi G, Govoni A, Bresolin N, Comi GP, Corti S.

Exp Neurol. 2011 - 30/06/2011

Publications 2010

Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells.

Nizzardo M, Simone C, Falcone M, Locatelli F, Riboldi G, Comi GP, Corti S.

Cell Mol Life Sci. 2010 - 30/11/2010

Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis.

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Simone C, Falcone M, Riboldi G, Govoni A, Bresolin N, Comi GP.

Hum Mol Genet. 2010 - 01/10/2010

Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice.

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Ronchi D, Simone C, Falcone M, Papadimitriou D, Locatelli F, Mezzina N, Gianni F, Bresolin N, Comi GP.

Brain. 2010 - 28/02/2010

Publications 2009

Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1).

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Del Bo R, Papadimitriou D, Locatelli F, Mezzina N, Gianni F, Bresolin N, Comi GP.

J Neurosci. 2009 - 23/09/2009

The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.

Di Fonzo A, Ronchi D, Lodi T, Fassone E, Tigano M, Lamperti C, Corti S, Bordoni A, Fortunato F, Nizzardo M, Napoli L, Donadoni C, Salani S, Saladino F, Moggio M, Bresolin N, Ferrero I, Comi GP.

Am J Hum Genet. 2009 - 31/05/2009

Publications 2008

Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy.

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Ronchi D, Saladino F, Bordoni A, Fortunato F, Del Bo R, Papadimitriou D, Locatelli F, Menozzi G, Strazzer S, Bresolin N, Comi GP.

J Clin Invest. 2008 - 03/10/2008

Publications 2007

Fas small interfering RNA reduces motoneuron death in amyotrophic lateral sclerosis mice.

Locatelli F, Corti S, Papadimitriou D, Fortunato F, Del Bo R, Donadoni C, Nizzardo M, Nardini M, Salani S, Ghezzi S, Strazzer S, Bresolin N, Comi GP.

Ann Neurol. 2007 - 31/07/2007

Isolation and characterization of murine neural stem/progenitor cells based on Prominin-1 expression.

Corti S, Nizzardo M, Nardini M, Donadoni C, Locatelli F, Papadimitriou D, Salani S, Del Bo R, Ghezzi S, Strazzer S, Bresolin N, Comi GP.

Exp Neurol. 2007 - 30/06/2007

Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model.

Corti S, Locatelli F, Papadimitriou D, Del Bo R, Nizzardo M, Nardini M, Donadoni C, Salani S, Fortunato F, Strazzer S, Bresolin N, Comi GP.

Brain. 2007 - 31/05/2007

Publications 2006

Identification of a primitive brain-derived neural stem cell population based on aldehyde dehydrogenase activity.

Corti S, Locatelli F, Papadimitriou D, Donadoni C, Salani S, Del Bo R, Strazzer S, Bresolin N, Comi GP.

Stem Cells. 2006 - 30/04/2006

Transplanted ALDHhiSSClo neural stem cells generate motor neurons and delay disease progression of nmd mice, an animal model of SMARD1.

Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Crimi M, Bordoni A, Fortunato F, Strazzer S, Menozzi G, Salani S, Bresolin N, Comi GP.

Hum Mol Genet. 2006 - 15/01/2006

Publications 2005

Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells.

Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Fortunato F, Strazzer S, Salani S, Bresolin N, Comi GP.

FASEB J. 2005 - 30/11/2005

Publications 2004

Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues.

Corti S, Locatelli F, Donadoni C, Guglieri M, Papadimitriou D, Strazzer S, Del Bo R, Comi GP.

Brain. 2004 - 30/11/2004

Improvement of combined FISH and immunofluorescence to trace the fate of somatic stem cells after transplantation.

Donadoni C, Corti S, Locatelli F, Papadimitriou D, Guglieri M, Strazzer S, Bossolasco P, Salani S, Comi GP.

J Histochem Cytochem. 2004 - 31/10/2004

Developmental and tissue-specific regulation of a novel dysferlin isoform.

Salani S, Lucchiari S, Fortunato F, Crimi M, Corti S, Locatelli F, Bossolasco P, Bresolin N, Comi GP.

Muscle Nerve. 2004 - 30/09/2004

Publications 2003

Neuronal differentiation of murine bone marrow Thy-1- and Sca-1-positive cells.

Locatelli F, Corti S, Donadoni C, Guglieri M, Capra F, Strazzer S, Salani S, Del Bo R, Fortunato F, Bordoni A, Comi GP.

J Hematother Stem Cell Res. 2003 - 31/12/2003

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