The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients


10.30 Welcome Notes and Update of the “International Research Staff Exchange Scheme (IRSES) – Marie Curie Actions – NO-MND” by Dr. Stefania Corti, PI of NO-MND and Program Coordinator, Milan University

10:45 “Introduction to MNDs” by Dr. Dimitra Papadimitriou, Co-Investigator of NO-MND, Biomedical Research Foundation Academy of Athens, Greece.

11:15 “A TSPO ligand improves motor performance and muscle innervation in a mouse model of amyotrophic laterals sclerosis“ by Dr. Diane Re, US Coordinator of the exchanges, Columbia University, New York, USA

11:45 “Axonal and synaptic genes with altered expression in human Spinal Muscular Atrophy motor neurons: molecular and therapeutic implications” by Dr. Federica Rizzo and Michela Taiana, Stefania Corti Laboratory, Milan University.

12:15 “Studying and modelling molecular mechanisms of neurodegeneration in Motor neuron diseases” by Dr. Paola Rinchetti, Stefania Corti Laboratory, Milan University.

12.40-13 Discussion


13-14.15 Lunch


14:15 “MiRNA profiling of ALS iPSCs and iPSC-derived motor neurons: molecular and therapeutic implication” by Dr. Mafalda Rizzuti and Dr. Valentina Melzi, Stefania Corti Laboratory, Milan University.

14:45 “Impaired mtDNA maintenance and neurodegeneration” by Dr. Dario Ronchi, Milan University

15:15 “ Mitochondrial dysfunction in iPSC-derived neurons of Multiple System Atrophy”, by Dr. Giacomo Monzio Compagnoni, Dr. Alessio Di Fonzo Laboratory, Milan University

15.45-16 Conclusive Remarks and Closing

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